III Frontiers in membrane Protein Structural Dynamics
APS Conference Center, Argonne National Lab
Friday, November 10
| 7:45 | Continental Breakfast, APS 402 Atrium |
| 8:15 | Eduardo Perozo (University of Chicago), Stephen Streiffer (Advanced Photon Source) Welcome and overall perspective |
Session I: ABC Transporters and Partners: Dynamics at the Edge of Stability
| 8:25 | Christine Ziegler (Universität Regensburg) Introduction |
| 8:30 | Doug Rees (Caltech University) ABC transporters and the alt-access movement |
| 8:55 | Show-Ling Shyng (Oregon Health & Science University) Illumination of the SUR1-Kir6.2 partnership in KATP channels by single-particle cryo-EM |
| 9:20 | Heather Pinkett (Northwestern University) The role of ABC transporters in nutrient uptake and pathogenesis |
| 9:45 | Break, APS 402 Atrium |
Session II: Technology Advances in Protein Expression and Engineering
| 10:25 | Chris Ahern (University of Iowa) Introduction |
| 10:30 | Anthony Kossiakoff (University of Chicago) Synthetic Antibodies to facilitate structural analyses of functional conformational intermediates by both crystallography and Cryo-EM |
| 10:55 | Bill Clemons (Caltech University) Solving the membrane protein expression problem |
| 11:20 | Andrew Kruse (Harvard University) New technologies to interrogate membrane protein function |
| 11:45 | Lunch, APS 402 – Lower Gallery |
Session III: Pumping Ions and Other Flotsam
| 1:00 | Francisco Bezanilla (University of Chicago) Introduction |
| 1:05 | Bernd Fakler (University of Freiburg, Germany) Native PMCAs – proteomic surprises with old Ca2+-pumps |
| 1:30 | Miguel Holmgren (National Institutes of Health) Dynamics of the Na/K ATPase with the binding/unbinding of external Na ions |
| 1:55 | Huan Rui (University of Chicago) Probing the cycling mechanism of the P-type ATPase: Insights from kinetic modeling simulations |
| 2:20 | Break, APS 402 Atrium |
Session IV: Poster Rapid Fire
| 2:50 | Yeon-Kyun Shin (Iowa State University) Introduction |
| 2:55 | Poster presenters 2 minute talks |
Session V: Keynote Speaker 1
| 4:45 | A Brief Vignette Honoring Jean Chin (Eduardo Perozo, University of Chicago) |
| 5:00 | Alessio Accardi (Weill Cornell University) Introduction |
| 5:10 | Christopher Miller (Brandeis University) How channel crystallography made me stupid |
| 6:00 | Dinner, APS 402 – Lower Gallery Posters, APS 402 – E1100/E1200 |
Saturday, November 11
Session VI: Calculating Conformational Changes: At the Bleeding Edge
| 7:45 | Continental Breakfast, APS 402 Atrium |
| 8:25 | Wonpil Im (LeHigh University) Introduction |
| 8:30 | Benoit Roux (University of Chicago) C-type Inactivation and the Constricted-Like Conformations of the Selectivity Filter of K+ Channels |
| 8:55 | Michael Grabe (University of California, San Francisco) TMEM16 lipid scrambles bend membranes to get things done |
| 9:20 | Jose Faraldo-Gomez (National Institutes of Health) The Dos and Don’ts of the Alternating-Access Mechanism: Lessons from the Sodium-Calcium Exchanger |
| 9:45 | Break, APS 402 Atrium |
Session VII: Protein Motion Within a Field: Ins and Outs of Voltage-dependent Gating
| 10:25 | Sudha Chakrapani (Case Western Reserve University) Introduction |
| 10:30 | Jian Yang (Columbia University) Cryo-EM structure of a eukaryotic cyclic nucleotide-gated channel |
| 10:55 | Bonnie Wallace (Birbeck, University of London) Structural, Function and Disease-Related Aspects of Sodium Channel Voltage-Gating |
| 11:20 | Francisco Bezanilla (University of Chicago) Voltage sensors and membrane capacitance |
| 11:45 | Rama Ranganthan (University of Chicago) Protein mechanics: the link between structure, function, and evolution |
| 12:10 | Lunch, APS 402 – Lower Gallery |
Session VIII: Structure and Dynamics with Few Molecules (or a Lot)
| 1:25 | Valeria Vasquez (University of Tennessee, Memphis) Introduction |
| 1:30 | Robert Fischetti (APS, Argonne National Lab) Serial crystallography with monochromatic and polychromatic X-ray beams, and the APS Upgrade |
| 1:55 | Yeon-Kyun Shin (Iowa State University) Zooming in on single vehicle fusion |
| 2:20 | Simon Scheuring (Weill Cornell University) High-Speed Atomic Force Microscopy: A New Tool for the Study of the Dynamics of Single Unlabeled Membrane Proteins |
| 2:45 | Break, APS 402 Atrium Posters, APS 401 – E1100/E1200 |
Session IX: The Good, the Bad and the Ugly: Conformational Changes and the Transport/Translocation Cycle
| 4:30 | Ming Zhou (Baylor University) Introduction |
| 4:35 | Filipo Mancia (Columbia University) The Molecular Mechanisms Underlying Cellular Uptake of Vitamin A |
| 5:00 | Aurelio Galli (University of Vanderbilt) Failure to Prime the Dopamine ‘Pump’ in Autism |
| 5:25 | Alessio Accardi (Weill Cornell University) Exploring the backdoor of CLC channels and transporters: how a glutamate gets in and out of the Cl- permeation pathway |
| 5:50 | Dinner, APS 402 – Lower Gallery Posters, APS 401 – E1100/E1200 |
Sunday, November 12
Session X: Structural Dynamics Through Imaging
| 9:00 | Tobin Sosnick (University of Chicago) Introduction |
| 9:05 | Christine Ziegler (Universität Regensburg) Being in the right place: Localization-dependent lipid interactions in the PC2 TRP Channel |
| 9:30 | Irina Serysheva (University of Texas Houston) Structure of IP3R Channel: Towards Understanding Gating Mechanism |
| 9:55 | Vera Moiseenkova-Bell (University of Pennsylvania) Molecular mechanism of the TRPV2 channel pore dynamics during ligand activation |
| 10:20 | Mingley Zhao (University of Chicago) Molecular Mechanism of SNARE Complex Disassembly |
| 10:55 | Break, APS 402 – Atrium |
Session XI: Keynote Speaker 2
| 11:05 | Robert Nakamoto (University of Virginia) Introduction |
| 11:15 | Olga Boudker (Weill Cornell University) Dynamic underpinnings of transport mechanism in glutamate transporters |
Closing
*Shuttle service from the guest house to the conference center will start 15 minutes prior to the start of the meeting.
*Shuttle service from the conference center to the guest house will run for 15 minutes after the poster session (9:00pm).
